Computational Biology

Computational Biology

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Ogun Adebali
Molecular Evolution

Molecular evolution is an area investigating the changes in DNA and protein molecules. Evolutionary events help us gain insights into the history and present of the biological events.

Our research aims to understand evolutionary history of proteins. The conservation profiles of proteins shed light into their function, potential partners and the evaluation of human variants in the disease context. We are specifically interested in eukaryotic signal transduction initiated by G protein-coupled receptors. Moreover, we develop novel approaches and tools in phylogenetics to increase the performance of amino acid substitution prediction. Our studies help identifying mutations causing rare diseases. For more information, please visit our lab website.

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Genome Integrity

Our research aims to understand how cells maintain their genome integrity through DNA repair mechanisms. We are interested in identifying the genomic factors playing role in nucleotide excision repair. We specifically focus on the formation and removal of DNA bulky adducts caused by ultraviolet and chemicals found in cigarette smoke, car exhaust and air pollution. For more information please visit our lab website.

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