Post-transcriptional gene regulation / Translation Control / Protein synthesis
Cancer cells regulate gene expression at multiple levels. While transcription has been the main focus, post-transcriptional regulation is now recognized as a key driver of cancer progression and a source for potential therapeutic targets.
Our research focuses on understanding the previously unknown connections between translation machinery and different cellular pathways that serve as novel cancer-specific vulnerabilities. We also study post-transcriptional regulation of key oncogenes and their non-canonical functions, using advanced in vitro and in vivo methods that integrate biochemistry, molecular biology, RNA biology, and cancer biology to uncover novel therapeutic targets.