Speaker: Roland Malli, Medical University of Graz

Title:  Investigating Cell Signaling and Metabolism by Light

Date/Time: December 5, 2019  /  12.40-13.30

Place: FENS L029

Abstract: The interplay of metabolic and signaling processes is prerequisite for the functionality of cells. Any disturbances may have severe consequences, resulting in the development of diseases. However, the complex coordination of metabolism and signaling events makes it difficult to decipher the link between molecular irregularities and pathogenesis. An excellent way to provide more clarity is to see into the living cell and watch cellular processes in real-time, with the add-on of being able to manipulate certain processes. Live cell imaging enables us to do exactly that, with steadily improving spatial and temporal resolution. These days, modern genetically encoded fluorescent probes in combination with state-of-the-art high-resolution imaging devices have proven themselves as a valuable approach for monitoring, manipulating and ultimately understanding the interaction of cell metabolism and signaling. In this talk, I will introduce several genetically encoded fluorescent probes and tools that have been recently developed in our lab.

BIO:  Roland Malli is an Associated Professor at the Medical University of Graz in Austria. His research team works at the Department of Molecular Biology and Biochemistry within the Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging. His main research focus is on the development, characterization and application of sophisticated genetically encoded fluorescent probes and tools. Roland Malli studied Pharmacy at the Karl-Franzenz University in Graz with suma cum laude and did is PhD study at the Department of Medical Biochemistry and Medical Molecularbiology at the Medical University of Graz. He received his habilitation in molecular and cellular physiology at the Medical University of Graz in 2017. Roland Malli published more than 100 journal articles and has several patent applications. Since 2016 he is CEO of NGFI (Next Generation Fluorescence Imaging), a company, which develops biosensors and instruments for live cell imaging.

Contact: Öznur Taştan